The "Institut de Science et d’Ingénierie Supramoléculaires" (ISIS) is an internationally-recognised institute that makes the most of a rather original modus operandi combining public and private laboratories together with start-ups. The senior teams, which include three Nobel laureates in Chemistry, and the junior scientists have carte blanche to develop pioneering ideas. Several private organisations benefit from this unique experience in their R&D. Early in 2019, five new research teams and three company branches will be able to join the success story following the construction of new buildings.